Revisão Sistemática do Estudo da Dinâmica de Estados Excitados da Tetraazaporfirina de Cobalto usando Surface Hopping
Resumo
A terapia fotodinâmica (TFD) é uma reação fotoquímica que atua diretamente em tecidos tumorais com intuito de destruí-los, quando aplicada de maneira ideal, sem afetar o tecido saudável. Caso um sensibilizador localize um tecido tumoral por este é anulado, devido à produção de espécies tóxicas como resultado da transferência de energia da molécula para o tecido tumoral, destruindo a anomalia de forma segura. Em sistemas naturais, a biossíntese do óxido de nitrogênio (NO) e suas várias reações biológicas e fisiológicas ocorrem através da interação com metaloproteínas de ferro, rutênio, cobre, cobalto, dentre outros metais de transição. Assim, as reações de NO através de sua coordenação com centros de metal de transição possuem grande potencial e são principais candidatos para cumprir essa função, podem ser citados porfirinas e seus derivados como a tetraazaporfirina.
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